One of the biggest challenges of conventional technologies is the long timelines to advance through scale-up.

In this particular instance, the lack of chromatography and of multi-stage synthesis meant that we actually were able to move from one liter scale to a hundred liter scale in a matter of a couple of days. When we reached the end of that and we had achieved this 99% conversion, I was really surprised and really pleased with the robustness of the enzyme.